We mainly focus our research effort on identifying specific cancer diagnostic or prognostic biomarkers to improve the management of cancer. In collaboration with our academic and industrial partners, we have several projects ongoing.
Profiling the genetic and epigenetic core signatures for gastrointestinal cancers at different stages
In each cancer genome, among the many diversified genetic mutations, some are driver gene mutations, and the remaining large amount are passenger mutations. Next generation sequencing (NGS) makes it feasible to study cancer genome globally.
The aim of this project is to profile the genetic and epigenetic alterations of cancer cells, and to provide insight into cancer initiation, progression, early diagnosis, and prognosis.
Characterization and validation of key molecular changes identified in cancers
In last decade, a number of molecules, including proteins, miRNAs, mRNAs, and specific metabolites have been suggested to be biomarkers of different types of cancers. Our research seeks to further characterize and validate these molecules, and to evaluate the feasibility of applying these molecules to our diagnostic development.